| Arm 1 (Triplet) |
Perioperative Imfinzi + Imjudo + Neoadjuvant EV |
Statistically significant & clinically meaningful improvement |
Favorable directional trend (not yet statistically significant) |
Consistent with known individual profiles; no new signals |
| Arm 2 (Doublet) |
Perioperative Imfinzi + Neoadjuvant EV |
Statistically significant & clinically meaningful improvement |
Statistically significant & clinically meaningful improvement |
Consistent with known individual profiles; no new signals |
| Arm 3 (Control) |
Radical Cystectomy ± approved adjuvant therapy |
Standard of care baseline |
Standard of care baseline |
Standard surgical risk baseline |
