Researchers at Mass General Brigham have developed a promising nasal spray for gene therapy, aiming to deliver treatments directly to the lungs. This innovation could offer a less invasive and more effective approach for genetic lung diseases like cystic fibrosis.
Biotechnology
Trastuzumab is a monoclonal antibody that has been engineered to attack and block the human epidermal growth factor receptor 2 (HER2), a protein that contributes to cancer cell growth. It is used most frequently to treat HER2-positive breast cancer and HER2-positive gastric cancer. As a targeted agent, trastuzumab has greatly enhanced treatment outcomes for patients with tumors that overexpress HER2. Mechanism of Action Trastuzumab is a humanized IgG1 monoclonal antibody that selectively binds to the extracellular domain (subdomain IV) of the […]
The computer program forecasts individual strands of DNA building blocks (A, T, C, and G) needed to create desired patterns of gene expression in various types of cells.
Compared to existing CAR T treatments, the off-the-shelf experimental therapeutic CTX112TM may allow for quicker patient access.
New active components, such as antibodies, are often evaluated separately in laboratory animals. Researchers at UZH have now created a method that can test up to 25 antibodies in a single mouse. This could not only accelerate the research and development pipeline for new pharmaceuticals, but also significantly reduce the number of experimental animals needed.
Bioreactors are specialized containers that allow the controlled development of cells, enzymes, or microbes. Environmental engineering, biotechnology, and pharmaceuticals are just a few of the disciplines in which they are essential. What is a Bioreactor? A bioreactor is an equipment or container that offers a regulated setting for biological processes […]
Utilizing reduced Takumi-shaped DNA nanostructures, researchers create optimal DNA hydrogels with possible biological uses.
According to the researchers, these recurring patterns suggest potential therapeutic targets meant to prevent or slow the progression of cancer.
Although embryonic cells exhibit amazing adaptability at this dynamic stage of early development, it is still unknown what molecular mechanisms and variables govern this plasticity.
Researchers at the University of Würburg (JMU), under the direction of Professor Claudia Höbartner, have recently discovered the three-dimensional structure of SAMURI, a particularly unique ribozyme.
