A Phase 1/2 trial included 15 individuals in total, among them three pediatric patients. The patients all suffered from the disease Leber congenital amaurosis caused by a gene that is essential in making proteins crucial to vision.
Healthcare & Pharmaceuticals
The rates of heart failure events and cardiovascular death were lower in the finerenone group compared with the placebo group.
Results showed that the deletion of a protein, OpgH, in a model bacterium, Caulobacter crescentus, sets off an event cascade that ultimately splits apart the protective, bubble-like cell envelope, eventually killing the cell.
Six out of eleven nonhuman primates who received an inoculation against the 1918 flu virus, which was prevalent a century ago, reportedly withstood exposure to H5N1, one of the worst viruses now circulating in the globe. On the other hand, six uninfected monkeys in the control group that were infected with the H5N1 virus died from the illness.
This new study offers a broadly useful technique to improve nanobodies’ performance. Artificially created antibody fragments, known as nanobodies, are around 10 times smaller than regular antibodies.
Delivering a healthy copy of a gene to a person whose gene(s) are malfunctioning is known as gene therapy.
Researchers at Scripps Research have recently discovered that when taken with checkpoint inhibitors, the immunosuppressive medication ruxolitinib, which is licenced, enhanced T-cell responses and increased the drugs’ ability to fight cancer.
This research appears to be the first to investigate the relationship between gut microbiota, brain function, and resilience.
Despite being influenced by prior vaccinations, the new vaccine produces widely neutralizing antibodies in response.
Research establishes foundation for clinical experiment targeted at averting brain tumours in kids with NF1.
