Single Cell Atlas; a pioneer for biomedical research

The goal is to produce an essential instrument that will assist researchers globally in understanding more about human health and illness.

Karolinska Institutet researchers have created a web-based platform that offers a whole new perspective on the human body at the molecular level. The goal is to produce an essential instrument that will assist researchers globally in understanding more about human health and illness. Genome Biology has published the work.

Deep and thorough profiling of human biology is made possible by multi-omics, the simultaneous measurement of several biomolecular characteristics. Based on examinations of hundreds of human tissue samples from 125 distinct adult and fetal tissues, the new Single Cell Atlas (SCA) was created. To map and localise the genes expressed in the tissue, the researchers utilised eight state-of-the-art omics methods, including whole-genome sequencing, spatial transcriptomics, and single-cell RNA sequencing.

The platform offers distinct perspectives on the characteristics of individual cells and their interplay within tissues. The platform’s website provides free access to the vast data collection.

The Single Cell Atlas not only saves time and resources but also fosters a collaborative environment for scientists from diverse fields, paving the way for new discoveries and innovations.

Lu Pan, researcher at the Institute of Environmental Medicine, Karolinska Institutet. (First Author)

In the future, the team intends to improve the SCA by adding yearly updates and more thorough assessments. By enhancing tissue representation and increasing sample size, these improvements will enable more accurate research.

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The creation of the SCA marks a significant step forward in biomedical research,

Our goal is to continually enrich the atlas, making it an invaluable resource for understanding human health and disease.

Xuexin Li, researcher at the Department of Physiology and Pharmacology

Source: Karolinska Institutet News

Journal Reference: Pan, Lu, et al. “Single Cell Atlas: a single-cell multi-omics human cell encyclopedia.” Genome Biology 25.1 (2024): 1-21. DOI: https://doi.org/10.1186/s13059-024-03246-2


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