Trastuzumab is a monoclonal antibodyĀ thatĀ has been engineeredĀ toĀ attackĀ andĀ blockĀ the human epidermal growth factor receptor 2 (HER2), a protein thatĀ contributesĀ toĀ cancerĀ cellĀ growth. It isĀ usedĀ mostĀ frequentlyĀ toĀ treatĀ HER2-positive breast cancer and HER2-positiveĀ gastric cancer. As a targetedĀ agent, trastuzumab hasĀ greatlyĀ enhancedĀ treatmentĀ outcomes for patientsĀ withĀ tumorsĀ thatĀ overexpress HER2. Mechanism of Action Trastuzumab is a humanized IgG1 monoclonal antibody thatĀ selectivelyĀ bindsĀ to the extracellular domain (subdomain IV) of the […]

XTANDIĀ® (enzalutamide), co-developed by Astellas and Pfizer, has shown a significant 30% reduction in risk of death over five years in metastatic hormone-sensitive prostate cancer (mHSPC) patients, marking it as the first androgen receptor inhibitor to demonstrate this long-term survival benefit.