Slept, starved myself, exercised, green porridge, black coffee-healthy social life.
There’s a mountain of advice on how to live a good, long life. Researchers do their best to figure out why some people live longer than others and how to get the most out of our increasingly long lives.
Their findings were published in the journal Nature Communications.
Now, a breakthrough has come from a team of scientists at the Center for Healthy Aging, Department of Cellular and Molecular Medicine at the University of Copenhagen. Researchers found that among all proteins, one protein-OSER1, greatly influences longevity.
We identified this protein that can extend longevity (long duration of life, red.). It is a novel pro-longevity factor, and it is a protein that exists in various animals, such as fruit flies, nematodes, silkworms, and in humans.
Lene Juel Rasmussen
The researchers draw the conclusion that the new findings also apply to humans because the protein is found in a variety of species.
The researchers draw the conclusion that the new findings also apply to humans because the protein is found in a variety of species.
A protein that was commonly present both in several animal models and in humans was identified, screening the proteins, which were followed by correlating data from animal subjects with the human cohort employed in the study. These correlations would allow us to determine whether or not the findings are translatable into human application.
We identified a protein commonly present in different animal models and humans. We screened the proteins and linked the data from the animals to the human cohort also used in the study. This allows us to understand whether it is translatable into humans or not,
If the gene only exists in animal models, it can be hard to translate to human health, which is why we, in the beginning, screened the potential longevity proteins that exist in many organisms, including humans. Because at the end of the day we are interested in identifying human longevity genes for possible interventions and drug discoveries.
Zhiquan Li
A protein that was commonly present both in several animal models and in humans was identified, screening the proteins, which were followed by correlating data from animal subjects with the human cohort employed in the study. These correlations would allow us to determine whether or not the findings are translatable into human applications.
We found 10 genes that, when – we manipulated their expression – longevity changed. We decided to focus on one of these genes that affected longevity most, called the OSER1 gene,
Zhiquan Li
A protein that was commonly present both in several animal models and in humans was identified, screening the proteins, which were followed by correlating data from animal subjects with the human cohort employed in the study. These correlations would allow us to determine whether or not the findings are translatable into human application.
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We are currently focused on uncovering the role of OSER1 in humans, but the lack of existing literature presents a challenge, as very little has been published on this topic to date. This study is the first to demonstrate that OSER1 is a significant regulator of aging and longevity. In the future, we hope to provide insights into the specific age-related diseases and aging processes that OSER1 influences.
Zhiquan Li
Additionally, the discovery and characterisation of OSER1 is expected to open up new therapeutic options for age-related conditions such metabolic, cardiovascular, and neurodegenerative illnesses.
Thus, the discovery of this new pro-longevity factor allows us to understand longevity in humans better.
Zhiquan Li
Source: University of Copenhagen – News
Journal Reference: Song, Jiangbo, et al. “FOXO-regulated OSER1 Reduces Oxidative Stress and Extends Lifespan in Multiple Species.” Nature Communications, vol. 15, no. 1, 2024, pp. 1-18, DOI: https://doi.org/10.1038/s41467-024-51542-z.
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